An improved efficient synthesis of the antibacterial agent torezolid.

نویسندگان

  • Gang Li
  • Bao-Kun Yuan
  • Wu Tang
  • Hong-Yi Zhao
  • Zi-Yun Lin
  • Hai-Hong Huang
چکیده

An improved and efficient method for the preparation of torezolid based on Suzuki cross-coupling reaction as the key step was developed on a gram scale in five steps. The total yield was 44% and the optical purity of torezolid by the improved method was above 99%.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 63 2  شماره 

صفحات  -

تاریخ انتشار 2015